嗜酸性粒细胞性肺炎患者支气管肺泡灌洗液中白细胞介素-18水平升高。
Elevated interleukin-18 levels in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia.
作者信息
Katoh S, Matsumoto N, Matsumoto K, Fukushima K, Matsukura S
机构信息
Third Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
出版信息
Allergy. 2004 Aug;59(8):850-6. doi: 10.1111/j.1398-9995.2004.00492.x.
BACKGROUND
Interleukin (IL)-18 can induce Th2 cytokine production particularly in collaboration with IL-2. Accumulation of Th2 cells and increased levels of Th2 cytokines are found in bronchoalveolar lavage fluid (BALF) from patients with eosinophilic pneumonia (EP). To evaluate the role of IL-18 in the pathogenesis of EP, we measured the concentration of IL-2, IL-12, IL-18, and Th2 cytokines in BALF from patients with EP.
METHODS
The concentrations of interferon (IFN)-gamma, IL-2, IL-5, IL-10, IL-12, IL-13, and IL-18 in BALF were measured in patients with idiopathic acute eosinophilic pneumonia (AEP), with idiopathic chronic eosinophilic pneumonia (CEP), with sarcoidosis and healthy volunteers (HV).
RESULTS
The BALF concentrations of Th2 cytokines, IL-5, IL-10, and IL-13, were higher in patients with EP than in sarcoidosis and control. The IL-2 level in BALF was higher in EP than in sarcoidosis and control. The IL-18 and IL-12 (p40 + p70) levels were higher in patients with EP than sarcoidosis, while the level of IL-12 (p70) was below the detection limit in patients with EP. There was a significant correlation between IL-2 level and both IL-5 and IL-13 in BALF of patients with EP.
CONCLUSIONS
Our findings suggest that IL-18 may contribute to Th2 cytokine-dominant responses in patients with EP in collaboration with IL-2.
背景
白细胞介素（IL）-18 尤其在与 IL-2 协同作用时可诱导 Th2 细胞因子的产生。在嗜酸性粒细胞性肺炎（EP）患者的支气管肺泡灌洗液（BALF）中发现 Th2 细胞积聚且 Th2 细胞因子水平升高。为评估 IL-18 在 EP 发病机制中的作用，我们测定了 EP 患者 BALF 中 IL-2、IL-12、IL-18 和 Th2 细胞因子的浓度。
方法
测定了特发性急性嗜酸性粒细胞性肺炎（AEP）、特发性慢性嗜酸性粒细胞性肺炎（CEP）、结节病患者及健康志愿者（HV）BALF 中干扰素（IFN）-γ、IL-2、IL-5、IL-10、IL-12、IL-13 和 IL-18 的浓度。
结果
EP 患者 BALF 中 Th2 细胞因子 IL-5、IL-10 和 IL-13 的浓度高于结节病患者和对照组。EP 患者 BALF 中的 IL-2 水平高于结节病患者和对照组。EP 患者的 IL-18 和 IL-12（p40 + p70）水平高于结节病患者，而 EP 患者的 IL-12（p70）水平低于检测限。EP 患者 BALF 中 IL-2 水平与 IL-5 和 IL-13 均显著相关。
结论
我们的研究结果表明，IL-18 可能与 IL-2 协同作用，促使 EP 患者出现以 Th2 细胞因子为主导的反应。
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