帕金森病危险因素及其交互作用的研究

[Study on the risk factors and its interaction on Parkinson disease].

作者信息

Tan Xian-Hua, Wang Shu-Mei, Xue Nan-Qing, Teng Wen-Tao, Feng Yue-Qiu

机构信息

Shandong Sport Research Center, Jinan 250002, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Jun;25(6):527-30.

PMID:15231138

Abstract

OBJECTIVE

To explore the risk factors of Parkinson disease (PD), interaction between family history of PD and other risk factors, as well as the relative strength of genetic factors over the vulnerability of PD.

METHODS

One 1:1 matched case-control study including 157 pairs of cases and controls was conducted in Qilu Hospital of Shandong University.

RESULTS

Conditional logistic regression analysis showed that family history of PD, mental labor, insecticide, alcohol drinking and history of depression all had positive relationship, while smoking had a negative relationship with PD. The AP (AB)s of family history of PD and insecticide, alcohol drinking, history of depression were 55.2%, 34.0%, 41.4% and the RERIs were 8.96, 3.31, 7.85 respectively. The heritability of PD patients' first degree relatives was 36.86% +/- 5.76%, and second degree relatives was 20.66% +/- 6.81%.

CONCLUSION

Family history of PD had an additive model synergism on PD, coexisting with other risk factors. Genetic factors had a smaller action on PD than environmental factors.

摘要

目的

探讨帕金森病（PD）的危险因素、PD家族史与其他危险因素之间的相互作用，以及遗传因素对PD易感性的相对强度。

方法

在山东大学齐鲁医院进行了一项1:1匹配的病例对照研究，包括157对病例和对照。

结果

条件logistic回归分析显示，PD家族史、脑力劳动、接触杀虫剂、饮酒和抑郁史均与PD呈正相关，而吸烟与PD呈负相关。PD家族史与杀虫剂、饮酒、抑郁史的归因比例（AP）分别为55.2%、34.0%、41.4%，相对超额危险度（RERI）分别为8.96、3.31、7.85。PD患者一级亲属的遗传度为36.86%±5.76%，二级亲属为20.66%±6.81%。