Shao Chuan, Wang Xiaoya, Wang Pan, Tang Hui, He Jiaquan, Wu Nan
Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.
Department of Neurosurgery, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China.
Front Nutr. 2021 Oct 14;8:709846. doi: 10.3389/fnut.2021.709846. eCollection 2021.
The association between Parkinson's disease (PD) risk and alcohol intake is a controversial topic. To systematically assess the association between PD risk and alcohol intake. PubMed and Embase databases were searched for eligible studies with prospective design on PD risk and alcohol intake. A meta-analysis with a random-effects model and dose-response analysis was performed. Relative risk ratios (RRs) with 95% CIs were calculated. Eleven prospective studies were included. Overall, a higher intake of alcohol was inversely associated with PD risk (RR: 0.81, 95% CI: 0.70-0.95, = 73.7%). Significant differences existed between the specific types of alcoholic beverages and geographic area. Specifically, a significant association existed for beer (RR: 0.78, 95% CI: 0.65-0.94, = 0.0%) and studies conducted in Asia (RR: 0.66, 95% CI: 0.55-0.80, = 37.3%). Dose-response analysis indicated a nonlinear relationship between PD risk and alcohol exposure. No evidence for publication bias was detected. In summary, our meta-analysis suggests that alcohol consumption was associated with a decreased risk of PD, with a nearly U-shaped association. Future studies are warranted to clarify the question of a specific type of alcoholic beverage-dependent association, geographic area effect, and possible threshold effects regarding both the adverse and beneficial effects of alcohol.
帕金森病（PD）风险与酒精摄入量之间的关联是一个有争议的话题。为了系统评估PD风险与酒精摄入量之间的关联，我们在PubMed和Embase数据库中检索了有关PD风险和酒精摄入量的前瞻性设计的合格研究。进行了随机效应模型的荟萃分析和剂量反应分析。计算了95%置信区间的相对风险比（RRs）。纳入了11项前瞻性研究。总体而言，酒精摄入量较高与PD风险呈负相关（RR：0.81，95%CI：0.70-0.95，I² = 73.7%）。不同类型的酒精饮料和地理区域之间存在显著差异。具体而言，啤酒（RR：0.78，95%CI：0.65-0.94，I² = 0.0%）以及在亚洲进行的研究（RR：0.66，95%CI：0.55-0.80，I² = 37.3%）存在显著关联。剂量反应分析表明PD风险与酒精暴露之间存在非线性关系。未检测到发表偏倚的证据。总之，我们的荟萃分析表明，饮酒与PD风险降低有关，呈近似U形关联。未来的研究有必要阐明特定类型酒精饮料依赖性关联、地理区域效应以及酒精利弊可能的阈值效应等问题。
