Müller U, Bircher A, Bischof M
Schweiz Med Wochenschr. 1986 Dec 20;116(51):1810-3.
Two patients are described who developed allergic angioedema following local anesthesia for dental surgery. Skin testing revealed that hyaluronidase from bull testes contained in one of the preparations used for local anesthesia was the responsible allergen. In both patients hyaluronidase-specific serum IgE antibodies were detected by RAST. Mammalian hyaluronidase, also called spreading factor, is believed to improve penetration of tissues by local anesthetics. It is used worldwide for this and other indications. In the presence of allergic reactions to local anesthetics the possibility of sensitization to hyaluronidase should be considered.
本文描述了两名患者，他们在牙科手术局部麻醉后发生了过敏性血管性水肿。皮肤试验显示，用于局部麻醉的一种制剂中所含的公牛睾丸透明质酸酶是致敏原。通过放射性变应原吸附试验（RAST）在两名患者中均检测到了透明质酸酶特异性血清IgE抗体。哺乳动物透明质酸酶，也称为扩散因子，被认为可改善局部麻醉药对组织的渗透。它在全球范围内用于此用途和其他适应症。在对局部麻醉药发生过敏反应的情况下，应考虑对透明质酸酶致敏的可能性。
