动脉狭窄建模及其在血液疾病中的应用。

Modeling of arterial stenosis and its applications to blood diseases.

作者信息

Pralhad R N, Schultz D H

机构信息

Faculty of Applied Mathematics, Institute of Armament Technology, Girinagar, Pune 411 025, Maharashtra, India.

出版信息

Math Biosci. 2004 Aug;190(2):203-20. doi: 10.1016/j.mbs.2004.01.009.

DOI:10.1016/j.mbs.2004.01.009

PMID:15234617

Abstract

Blood flow in a stenosed tube has been modeled in the present studies. Blood flow is assumed to be represented by a couple stress fluid. Flow parameters such as velocity, resistance to flow, and shear stress distribution have been computed for different suspension concentrations (haematocrit), and for the blood diseases; polycythemia, plasma cell dyscrasias, and for Hb SS (sickle cell). The results have been compared with the case of normal blood and for other theoretical models. The importance of size effects in blood flow studies has been highlighted.

摘要

在本研究中对狭窄血管中的血流进行了建模。假定血流由偶应力流体表示。针对不同的悬浮液浓度（血细胞比容）、血液疾病（真性红细胞增多症、浆细胞发育异常）以及血红蛋白SS（镰状细胞），计算了诸如速度、血流阻力和剪切应力分布等血流参数。已将结果与正常血液的情况以及其他理论模型进行了比较。强调了血流研究中尺寸效应的重要性。