Zhi Fa-Chao, Liu Xu-Ming, Liu Ze-Quan, Lin Yan, Chen Shu-Jian
PLA Institute for Digestive Medicine, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China.
World J Gastroenterol. 2004 Jul 15;10(14):2150-2. doi: 10.3748/wjg.v10.i14.2150.
To assess the therapeutic value of endoscopic nasobiliary drainage (ENBD) and oral praziquantel for severe Clonorchiasis sinensis infection.
Of the 84 Clonorchiasis sinensis-infected patients enrolled, 58 were treated with ENBD (as observing group, ENBD group), 26 received operations (control group, operation group). Both of the two groups were comparable in terms of patient's age, body mass index. Before and one week after treatment, the average diameters of common bile ducts were measured by ultrasound, and serum bilirubin, ALP, gamma-GT and ALT were detected by biochemical methods. After ENBD or operation, the patients took praziquantel for two days.
Compared with the patients in operation group, ENBD patients in ENBD group had higher recovery rates of abdominal pain and fever as well as jaundice, quicker remission, smaller trauma, fewer complications and lower cost.
ENBD combined with oral praziquantel is an effective and safe method for the treatment of severe Clonorchiasis sinensis.
评估内镜鼻胆管引流术（ENBD）联合口服吡喹酮治疗重度华支睾吸虫感染的治疗价值。
纳入84例华支睾吸虫感染患者，其中58例采用ENBD治疗（观察组，ENBD组），26例行手术治疗（对照组，手术组）。两组患者的年龄、体重指数具有可比性。治疗前及治疗1周后，采用超声测量胆总管平均直径，采用生化方法检测血清胆红素、碱性磷酸酶（ALP）、γ-谷氨酰转肽酶（γ-GT）及谷丙转氨酶（ALT）。ENBD或手术后，患者服用吡喹酮2天。
与手术组患者相比，ENBD组患者腹痛、发热及黄疸的恢复率更高，缓解更快，创伤更小，并发症更少，费用更低。
ENBD联合口服吡喹酮是治疗重度华支睾吸虫感染的一种有效且安全的方法。
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