Sugi Toshitaka, Matsubayashi Hidehiko, Inomo Akifumi, Dan Lu, Makino Tsunehisa
Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.
J Obstet Gynaecol Res. 2004 Aug;30(4):326-32. doi: 10.1111/j.1447-0756.2004.00206.x.
Associations have been reported between antiphospholipid antibodies (aPL), mainly anticardiolipin antibodies (aCL) and/or the lupus anticoagulant, and recurrent pregnancy losses (RPL). However, relatively few studies describing antiphosphatidylethanolamine antibodies (aPE) have been reported. We describe the prevalence of aPL to both cardiolipin and phosphatidylethanolamine in patients with RPL.
Patients with recurrent early pregnancy losses (n = 145) and mid-to-late pregnancy loss(es) (n = 26) were screened for aPE and aCL.
In patients with recurrent early pregnancy losses, prevalence of immunoglobulin G (IgG) aPE (17.9%, P = 0.001) and immunoglobulin M (IgM) aPE (12.4%, P = 0.01) was significantly higher than in the control group. In patients with mid-to-late pregnancy loss(es), prevalence of IgM aPE (19.2%, P = 0.008) and IgG aCL (23.1%, P = 0.02) was significantly higher than in the control group.
Our data suggest that aPE may be a risk factor in patients with mid-to-late pregnancy loss(es) as well as recurrent early pregnancy losses.
已有报道称抗磷脂抗体（aPL），主要是抗心磷脂抗体（aCL）和/或狼疮抗凝物，与复发性流产（RPL）之间存在关联。然而，描述抗磷脂酰乙醇胺抗体（aPE）的研究相对较少。我们描述了复发性流产患者中抗心磷脂和抗磷脂酰乙醇胺的aPL患病率。
对复发性早期流产患者（n = 145）和中晚期流产患者（n = 26）进行aPE和aCL筛查。
在复发性早期流产患者中，免疫球蛋白G（IgG）aPE的患病率（17.9%，P = 0.001）和免疫球蛋白M（IgM）aPE的患病率（12.4%，P = 0.01）显著高于对照组。在中晚期流产患者中，IgM aPE的患病率（19.2%，P = 0.008）和IgG aCL的患病率（23.1%，P = 0.02）显著高于对照组。
我们的数据表明，aPE可能是中晚期流产以及复发性早期流产患者的一个危险因素。
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