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本文引用的文献

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Seronegative antiphospholipid syndrome.抗磷脂抗体阴性的抗磷脂综合征。
Rheumatology (Oxford). 2013 Aug;52(8):1358-67. doi: 10.1093/rheumatology/ket126. Epub 2013 Mar 15.
2
Antiphosphatidylserine/prothrombin antibodies in primary antiphospholipid syndrome.原发性抗磷脂综合征中的抗磷脂酰丝氨酸/凝血酶原抗体。
Lupus. 2012 Jun;21(7):787-9. doi: 10.1177/0961203312441983.
3
The contribution of antiphosphatidylethanolamine antibodies in the diagnosis of the antiphospholipid syndrome.抗磷脂酰乙醇胺抗体在抗磷脂综合征诊断中的作用。
Lupus. 2012 Jun;21(7):727-8. doi: 10.1177/0961203312437272.
4
Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential markers of antiphospholipid syndrome.抗磷脂酰丝氨酸/凝血酶原抗体（aPS/PT）作为抗磷脂综合征的潜在标志物。
Clin Appl Thromb Hemost. 2013 Jun;19(3):289-96. doi: 10.1177/1076029612437578. Epub 2012 Mar 2.
5
Clinical manifestations of antiphospholipid syndrome (APS) with and without antiphospholipid antibodies (the so-called 'seronegative APS').抗磷脂综合征（APS）有和无抗磷脂抗体（所谓的“血清阴性 APS”）的临床表现。
Ann Rheum Dis. 2012 Feb;71(2):242-4. doi: 10.1136/annrheumdis-2011-200614. Epub 2011 Sep 27.
6
'Non-criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, USA, April 2010.“非标准”抗磷脂抗体检测：第 13 届国际抗磷脂抗体大会（美国得克萨斯州加尔维斯顿，2010 年 4 月）专题工作组及会前研讨会报告。
Lupus. 2011 Feb;20(2):191-205. doi: 10.1177/0961203310397082.
7
ELISA for antiphosphatidylethanolamine antibody detection: high impact of assay buffer on results.ELISA 法检测抗磷脂酰乙醇胺抗体：检测结果受试剂缓冲液影响较大。
J Immunol Methods. 2010 Jun 30;358(1-2):9-16. doi: 10.1016/j.jim.2010.04.002. Epub 2010 Apr 9.
8
Antiprothrombin antibody: why do we need more assays?抗凝血酶抗体：我们为何需要更多的检测方法？
Lupus. 2010 Apr;19(4):436-9. doi: 10.1177/0961203310361487.
9
Anti-beta(2)-glycoprotein-I and anti-phosphatidylserine antibodies in women with spontaneous pregnancy loss.抗β2-糖蛋白 I 抗体和抗磷脂酰丝氨酸抗体与不明原因自然流产的关系。
Fertil Steril. 2010 May 1;93(7):2330-6. doi: 10.1016/j.fertnstert.2009.01.089. Epub 2009 Mar 17.
10
Autoantibody explosion in antiphospholipid syndrome.抗磷脂综合征中的自身抗体激增。
J Autoimmun. 2008 Feb-Mar;30(1-2):74-83. doi: 10.1016/j.jaut.2007.11.011. Epub 2008 Jan 2.

复发性流产中多种抗磷脂抗体类型

Bouquet variety of antiphospholipid antibodies in recurrent pregnancy loss.

作者信息

Baleva Marta P, Karagyozova Zhivka P, Nikolova-Vlahova Milena K, Nikolov Krasimir V, Nikolov Petar K

机构信息

Medical University-Sofia, University Hospital Alexandrovska, Sofia, Bulgaria.

Medical University-Sofia, University Hospital Majchin Dom, Sofia, Bulgaria.

出版信息

Cent Eur J Immunol. 2014;39(3):352-6. doi: 10.5114/ceji.2014.45947. Epub 2014 Oct 14.

DOI:10.5114/ceji.2014.45947
PMID:26155147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4439996/
Abstract

Seventy-six female patients with two or more recurrent pregnancy losses (RPL) during the 1(st) trimester were studied. Based on the results of the aCL and aB2GPI antibodies testing, patients were divided in two groups: 22 patients with RPL and elevated immunoglobulin (Ig) G/IgM aCL and/or aB2GPI [RPL + antiphospholipid syndrome (APS)] and 54 patients with RPL alone (without high antibodies). Immunoglobulin G aPS and IgG a-AnV in patients with RPL + APS were higher than in controls and IgG aPS were higher in RPL + APS than in RPL alone. Additionally IgG a-AnV and IgM aPE are higher in RPL alone than in controls. In 18/22 (81%) patients with RPL + APS and 29/54 (54%) patients with RPL alone, there were one or more positive antibodies: aPS, aPT, a-AnV or aPE. These results raise a question whether or not these antiphospholipid antibodies should be routinely tested in women with RPL and especially in the context of the so-called "seronegative APS".

摘要

对76名在孕早期有两次或更多次复发性流产（RPL）的女性患者进行了研究。根据抗心磷脂抗体（aCL）和抗β2糖蛋白I抗体（aB2GPI）检测结果，将患者分为两组：22名患有RPL且免疫球蛋白（Ig）G/IgM aCL和/或aB2GPI升高的患者[RPL + 抗磷脂综合征（APS）]和54名单纯RPL患者（无高抗体）。RPL + APS患者的IgG抗磷脂抗体（aPS）和IgG抗心内膜抗体（a - AnV）高于对照组，且RPL + APS患者的IgG aPS高于单纯RPL患者。此外，单纯RPL患者的IgG a - AnV和IgM抗磷脂酰乙醇胺抗体（aPE）高于对照组。在18/22（81%）的RPL + APS患者和29/54（54%）的单纯RPL患者中，存在一种或多种阳性抗体：aPS、抗凝血酶原抗体（aPT）、a - AnV或aPE。这些结果提出了一个问题，即对于RPL女性，尤其是在所谓的“血清阴性APS”情况下，是否应该常规检测这些抗磷脂抗体。