Giles Julie, Hardick Justin, Yuenger Jeffrey, Dan Michael, Reich Karl, Zenilman Jonathan
Division of Allergies and Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
J Clin Microbiol. 2004 Jul;42(7):3281-3. doi: 10.1128/JCM.42.7.3281-3283.2004.
Mutations in quinolone resistance-determining regions (QRDRs) have been associated with quinolone-resistant Neisseria gonorrhoeae (QRNG). Since diagnostic nucleic acid amplification tests for gonococci are now in frequent use, molecular detection of QRNG could facilitate surveillance in the absence of culture. Here we describe a real-time molecular assay for detecting QRDR mutations in gonococci.
喹诺酮耐药决定区(QRDRs)的突变与耐喹诺酮淋病奈瑟菌(QRNG)有关。由于目前淋病奈瑟菌的诊断性核酸扩增检测经常使用,在无培养的情况下,QRNG的分子检测有助于监测。在此,我们描述一种用于检测淋病奈瑟菌QRDR突变的实时分子检测方法。