热休克蛋白与细菌感染期间的宿主-病原体相互作用。

Heat-shock proteins and the host-pathogen interaction during bacterial infection.

作者信息

Stewart Graham R, Young Douglas B

机构信息

Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

出版信息

Curr Opin Immunol. 2004 Aug;16(4):506-10. doi: 10.1016/j.coi.2004.05.007.

DOI:10.1016/j.coi.2004.05.007

PMID:15245747

Abstract

Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.

摘要

热休克蛋白（HSPs）在细菌病原体适应细胞内存活的过程中大量表达。宿主和病原体的热休克蛋白都通过受体介导的固有免疫反应激活以及参与适应性免疫反应的抗原呈递来促进免疫。对这些相互作用的操控为通过疫苗接种或免疫疗法更好地控制感染提供了一条潜在途径。