Athman Rafika, Philpott Dana
Immunité Innée et Signalisation, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France.
Curr Opin Microbiol. 2004 Feb;7(1):25-32. doi: 10.1016/j.mib.2003.12.013.
Host defense against microbes requires the development of an efficient immune response aimed to eradicate the source of infection. Through the expression of a battery of germ-line encoded receptors, including the Toll-like receptors and Nod proteins, the innate immune system, which is a prerequisite to the adaptive immune response, detects microbial motifs and initiates pro-inflammatory signaling. Current research into innate immune function focuses on the nature of the ligands detected by this system, the cell signaling that occurs downstream of receptor activation and finally, how these signals culminate into a tailored adaptive immune response directed to eradicate a specific infection.
机体抵御微生物需要产生有效的免疫反应以根除感染源。通过一系列种系编码受体（包括Toll样受体和Nod蛋白）的表达，先天免疫系统（适应性免疫反应的先决条件）检测微生物基序并启动促炎信号传导。目前对先天免疫功能的研究集中在该系统检测到的配体的性质、受体激活下游发生的细胞信号传导，以及最终这些信号如何 culminate 为针对根除特定感染的量身定制的适应性免疫反应。
“culminate”此处直译为“达到顶点”，放在语境中可意译为“最终促成”等更通顺的表达，但按要求未做调整。
