热休克蛋白受体：一些答案与更多问题

The heat-shock protein receptors: some answers and more questions.

作者信息

Binder R J, Vatner R, Srivastava P

机构信息

Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA.

出版信息

Tissue Antigens. 2004 Oct;64(4):442-51. doi: 10.1111/j.1399-0039.2004.00299.x.

DOI:10.1111/j.1399-0039.2004.00299.x

PMID:15361121

Abstract

The existence of heat-shock protein (HSP) receptors on antigen-presenting cells (APCs) was hypothesized in 1994. The first such receptor, CD91 or LRP, was identified and characterized in 2000. The pace of attribution has quickened since and during the last three years alone, six putative HSP receptors have been identified. These include CD40, LOX-1, CD36, Toll-like receptor-2 (TLR-2), TLR-4 and SR-A. The literature on HSP receptors on APCs is critically examined in this review and future directions are imagined.

摘要

1994年有人提出抗原呈递细胞（APC）上存在热休克蛋白（HSP）受体的假说。2000年，首个此类受体CD91或低密度脂蛋白受体相关蛋白（LRP）被鉴定并加以描述。自那时起，确认的速度加快，仅在过去三年间，就有6种假定的HSP受体被鉴定出来。这些受体包括CD40、凝集素样氧化低密度脂蛋白受体1（LOX-1）、CD36、Toll样受体2（TLR-2）、TLR-4和清道夫受体A（SR-A）。本文对有关APC上HSP受体的文献进行了批判性审视，并展望了未来的研究方向。