香港慢性乙型肝炎感染的乙肝病毒基因型、核心启动子及前核心区突变的流行病学研究

Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong.

作者信息

Yuen Man-Fung, Sablon Erwin, Tanaka Yasuhito, Kato Takanobu, Mizokami Masashi, Doutreloigne Joke, Yuan He-Jun, Wong Danny Ka-Ho, Sum Siu-Man, Lai Ching-Lung

机构信息

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China.

出版信息

J Hepatol. 2004 Jul;41(1):119-25. doi: 10.1016/j.jhep.2004.03.004.

DOI:10.1016/j.jhep.2004.03.004

PMID:15246217

Abstract

BACKGROUND/AIMS: We conducted a population study to document the prevalence of hepatitis B virus (HBV) genotypes in Hong Kong.

METHODS

HBV genotypes, core promoter (CP) and precore mutations were determined in 776 asymptomatic patients.

RESULTS

92.6% patients had single genotype [B (32.5%), C (62.5%)]. 99.1% of genotype B was subtype Ba. Patients with age <50 years had a lower prevalence of genotype B than patients with age >51 years (32.5% vs. 41%, respectively, P=0.028). Compared to patients with genotype C, patients with genotype B had a higher cumulative rate (P=0.018) and younger age (40.1 vs. 34.2 years, respectively, P=0.018) of HBeAg seroconversion. There were no differences in the HBV DNA levels between patients with genotypes B and C, and with wild-type and mutants of CP and precore regions. By multivariate analysis, patients with genotype C and with CP mutations had higher alanine aminotransferase (ALT) levels.

CONCLUSIONS

B and C were the two most common HBV genotypes in Hong Kong. The former had a higher chance of earlier HBeAg seroconversion and lower ALT levels. The prevalence of genotype B was lower in patients with age <50, probably related to influx of immigrants from China since 1949.

摘要

背景/目的：我们开展了一项群体研究，以记录香港乙型肝炎病毒（HBV）基因型的流行情况。

方法

对776例无症状患者进行了HBV基因型、核心启动子（CP）和前核心突变检测。

结果

92.6%的患者为单一基因型[B型（32.5%），C型（62.5%）]。99.1%的B基因型为Ba亚型。年龄<50岁的患者中B基因型的流行率低于年龄>51岁的患者（分别为32.5%和41%，P=0.028）。与C基因型患者相比，B基因型患者HBeAg血清学转换的累积发生率更高（P=0.018），且年龄更小（分别为40.1岁和34.2岁，P=0.018）。B基因型和C基因型患者之间，以及CP和前核心区野生型与突变型患者之间的HBV DNA水平无差异。多因素分析显示，C基因型和CP突变患者的丙氨酸氨基转移酶（ALT）水平更高。