评估自然选择对疟原虫的影响。
Assessing the effect of natural selection in malaria parasites.
作者信息
Escalante Ananias A, Cornejo Omar E, Rojas Ascanio, Udhayakumar Venkatachalam, Lal Altaf A
机构信息
Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020-A, Venezuela.
出版信息
Trends Parasitol. 2004 Aug;20(8):388-95. doi: 10.1016/j.pt.2004.06.002.
There are few concepts that have been used across disciplines; one of them is natural selection. The impact that this process has on parasite genetic diversity is reviewed here by discussing examples on drug resistance and vaccine antigens. Emphasis is made on how mechanisms need to be addressed rather than associations, and how such investigations were out of reach of biomedical researchers only a decade ago.
很少有概念能跨学科应用；自然选择就是其中之一。本文通过讨论耐药性和疫苗抗原方面的例子，回顾了这一过程对寄生虫遗传多样性的影响。重点强调了需要研究机制而非关联性，以及仅在十年前生物医学研究人员还无法进行此类调查。
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