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缅甸和越南间疟原虫红细胞结合抗原 175 区 II 的遗传多态性和自然选择。

Genetic polymorphism and natural selection of the erythrocyte binding antigen 175 region II in Plasmodium falciparum populations from Myanmar and Vietnam.

机构信息

Department of Parasitology and Tropical Medicine, and Institute of Health Science, Gyeongsang National University College of Medicine, Jinju, 52727, Republic of Korea.

Department of Convergence Medical Science, Gyeongsang National University, Jinju, 52727, Republic of Korea.

出版信息

Sci Rep. 2023 Nov 16;13(1):20025. doi: 10.1038/s41598-023-47275-6.

DOI:10.1038/s41598-023-47275-6
PMID:37973970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10654615/
Abstract

Plasmodium falciparum erythrocyte binding antigen 175 (PfEBA-175) plays essential role in erythrocyte invasion by the parasite and is a leading vaccine candidate. However, its genetic diversity in global isolates is a concern in developing an universal vaccine incorporating this protein. This study aimed to investigate genetic polymorphisms and natural selection of pfeba-175 region II (RII) in Myanmar and Vietnam P. falciparum isolates. Vietnam pfeba-175 RII displayed a low genetic polymorphism, while Myanmar pfeba-175 RII showed high levels of genetic diversity across the region. Point mutations, deletion, and recombinations were main factors contributing to genetic diversities in P. falciparum populations. Global pfeba-175 RII revealed similar, but not identical, genetic polymorphisms and natural selection profiles. Despite profiles of amino acid substitutions differed among populations, five major amino acid changes (K279E, E403K, K481I, Q584K, and R664) were commonly detected in global pfeba-175 RII populations. Haplotype network and genetic differentiation analyses of global pfeba-175 RII populations demonstrated no geographical relationships. Non-neglectable level of genetic diversity was observed in global pfeba-175 RII populations, emphasizing the need to consider this when designing an effective vaccine based on this protein. This study underscores the importance of the continuous monitoring of genetic diversity of pfeba-175 RII in the global P. falciparum populations.

摘要

恶性疟原虫红细胞结合抗原 175（PfEBA-175）在寄生虫入侵红细胞过程中起着至关重要的作用，是一种主要的疫苗候选蛋白。然而，其在全球分离株中的遗传多样性是开发包含这种蛋白质的通用疫苗的一个关注点。本研究旨在调查缅甸和越南恶性疟原虫分离株中 pfeba-175 区域 II（RII）的遗传多态性和自然选择。越南 pfeba-175 RII 显示出较低的遗传多态性，而缅甸 pfeba-175 RII 在整个区域表现出较高的遗传多样性水平。点突变、缺失和重组是导致疟原虫种群遗传多样性的主要因素。全球 pfeba-175 RII 显示出相似但不完全相同的遗传多态性和自然选择模式。尽管种群之间的氨基酸替换模式不同，但在全球 pfeba-175 RII 种群中普遍检测到五个主要的氨基酸变化（K279E、E403K、K481I、Q584K 和 R664）。全球 pfeba-175 RII 种群的单倍型网络和遗传分化分析表明没有地理关系。全球 pfeba-175 RII 种群中观察到不可忽视的遗传多样性水平，这强调了在基于该蛋白设计有效疫苗时需要考虑这一点。本研究强调了在全球恶性疟原虫种群中持续监测 pfeba-175 RII 遗传多样性的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/91bfe16978f3/41598_2023_47275_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/b463631c55ff/41598_2023_47275_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/91bfe16978f3/41598_2023_47275_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/ba5ce5340dd1/41598_2023_47275_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/40b962acd014/41598_2023_47275_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/146e2521a848/41598_2023_47275_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/fe05ad774cdb/41598_2023_47275_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/ba20f0ce10eb/41598_2023_47275_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/b463631c55ff/41598_2023_47275_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfe/10654615/91bfe16978f3/41598_2023_47275_Fig7_HTML.jpg

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