肾脏肾素-血管紧张素系统。
Renal renin-angiotensin system.
作者信息
Ichihara Atsuhiro, Kobori Hiroyuki, Nishiyama Akira, Navar L Gabriel
机构信息
Keio University School of Medicine, Tokyo, USA.
出版信息
Contrib Nephrol. 2004;143:117-30. doi: 10.1159/000078716.
Abstract
The cardinal role of the intrarenal renin-angiotensin system (RAS) in the control of sodium excretion and the pathophysiology of hypertension continues to receive increased attention. In addition to its very powerful vasoconstrictor action, angiotensin (Ang) II exerts important actions on tubular transport function and several recent studies have emphasized the potential importance of actions of angiotensin peptides on receptors localized to the luminal membranes of both proximal and distal nephron segments. Furthermore, a strong case is being developed supporting the importance of local mechanisms regulating the activity of the RAS. This is due to the fact that all components of the RAS are strongly expressed in the kidneys.
摘要
肾内肾素-血管紧张素系统（RAS）在控制钠排泄和高血压病理生理学中的主要作用一直受到越来越多的关注。除了其非常强大的血管收缩作用外，血管紧张素（Ang）II对肾小管转运功能也有重要作用，最近的几项研究强调了血管紧张素肽对定位于近端和远端肾单位节段管腔膜上受体的作用的潜在重要性。此外，越来越多的证据支持调节RAS活性的局部机制的重要性。这是因为RAS的所有成分在肾脏中都有强烈表达。
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