Altomonte L, Zoli A, Mirone L, Marchese G, Scolieri P, Barini A, Magarò M
Divisione di Reumatologia, Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma.
Ann Ital Med Int. 1992 Jan-Mar;7(1):30-3.
Serum insulin and C-peptide response to an oral glucose tolerance test (OGTT) and serum growth hormone (GH) response to an intravenous insulin tolerance test (IVITT) were investigated in six non-obese patients, with normal glucose tolerance, affected by diffuse idiopathic skeletal hyperostosis (DISH). Basal serum insulin, C-peptide and GH values were similar in DISH patients and in controls. After OGTT, insulin and C-peptide values were not significantly different in the two groups at any time interval. In contrast, after IVITT, a significant increase in GH concentrations was noted at 30 and 45 minutes in DISH patients when compared to controls. Growth hormone either acting alone or through somatomedin intermediaries results in new bone growth in acromegaly, and the same may be true for DISH. Recent reports suggest that GH promotes tissue growth by stimulating precursor cells in various tissues including cartilage and bone. The increased GH response to IVITT corroborates the hypothesis that GH may act as a bone growth-promoting factor in DISH.
在6例糖耐量正常、患有弥漫性特发性骨肥厚（DISH）的非肥胖患者中，研究了口服葡萄糖耐量试验（OGTT）后的血清胰岛素和C肽反应以及静脉胰岛素耐量试验（IVITT）后的血清生长激素（GH）反应。DISH患者和对照组的基础血清胰岛素、C肽和GH值相似。OGTT后，两组在任何时间间隔的胰岛素和C肽值均无显著差异。相比之下，IVITT后，与对照组相比，DISH患者在30分钟和45分钟时GH浓度显著升高。生长激素单独作用或通过生长调节素中间体起作用会导致肢端肥大症中出现新骨生长，DISH可能也是如此。最近的报告表明，GH通过刺激包括软骨和骨在内的各种组织中的前体细胞来促进组织生长。IVITT后GH反应增加证实了GH可能作为DISH中骨生长促进因子的假说。
