Denko C W, Boja B, Moskowitz R W
Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH.
J Rheumatol. 1994 Sep;21(9):1725-30.
To investigate growth factors influencing bone and cartilage in patients with diffuse idiopathic skeletal hyperostosis (DISH).
Standard radioimmunoassays (INCSTAR, Stillwater, MN) quantified serum levels of insulin, insulin-like growth factor-I (IGF-I) and growth hormone (GH) in patients with DISH, in patients with osteoarthritis (OA) and in controls. Patients with DISH with comorbidity with obesity, hypertension, diabetes and coronary artery disease, also were studied.
Patients with DISH demonstrated normal IGF-I levels; patients with OA had reduced IGF-I levels. Subjects with DISH or OA had elevated insulin and GH values. Patients with DISH with comorbidity had changes in growth factors similar to those found in patients with DISH only. There is frequent association of DISH with obesity, hypertension, coronary artery disease and diabetes mellitus suggesting that these associations are not random.
Specific associations of skeletal abnormalities with clinical features in which skeletal change and clinical features combine with disturbances of insulin, IGF-I and GH exist in DISH that are distinct from OA. DISH is considered a multisystemic hormonal disorder with protean presentations.
研究影响弥漫性特发性骨肥厚（DISH）患者骨骼和软骨的生长因子。
采用标准放射免疫分析法（INCSTAR，明尼苏达州斯蒂尔沃特）对DISH患者、骨关节炎（OA）患者及对照组的血清胰岛素、胰岛素样生长因子-I（IGF-I）和生长激素（GH）水平进行定量检测。同时对合并肥胖、高血压、糖尿病和冠状动脉疾病的DISH患者也进行了研究。
DISH患者的IGF-I水平正常；OA患者的IGF-I水平降低。DISH或OA患者的胰岛素和GH值升高。合并症的DISH患者生长因子的变化与单纯DISH患者相似。DISH常与肥胖、高血压、冠状动脉疾病和糖尿病相关，提示这些关联并非随机发生。
DISH存在骨骼异常与临床特征的特定关联，其中骨骼变化和临床特征与胰岛素、IGF-I和GH的紊乱相结合，这与OA不同。DISH被认为是一种具有多种表现形式的多系统激素紊乱疾病。
