Rajendran P, Spear L P
Department of Psychology, Binghamton University, P.O. Box 6000, State University of New York, Binghamton, NY 13902-6000, USA.
Ann N Y Acad Sci. 2004 Jun;1021:441-4. doi: 10.1196/annals.1308.060.
Adolescent rats have been reported to be less sensitive than adults to many acute ethanol effects, including ethanol-induced sedation and motor impairment, but conversely more sensitive to ethanol-induced disruptions in spatial memory in a Morris water maze (Markwiese et al., 1998). The present study examined adolescent and adult rats trained for 6 days under spatial or nonspatial versions of a presumably less stressful sand box maze. Moderately food-deprived animals were given 0, 0.5, or 1.5 g/kg ethanol intraperitoneally 30 min before training each day, but were tested without ethanol or reinforcer on test day. Spatial acquisition was impaired by 1.5 g/kg in adults but not adolescents, with no ethanol impairment on the nonspatial task at either age. These results are opposite the ontogenetic profile reported by Markwiese et al., (1998) and may reflect differential activation of prefrontal cortex or other stress-sensitive forebrain regions by the two tasks across age.
据报道，青春期大鼠对许多急性乙醇效应的敏感性低于成年大鼠，包括乙醇诱导的镇静和运动障碍，但相反，在莫里斯水迷宫中，它们对乙醇诱导的空间记忆破坏更为敏感（Markwiese等人，1998年）。本研究考察了在压力较小的沙箱迷宫的空间或非空间版本下训练6天的青春期和成年大鼠。适度食物剥夺的动物在每天训练前30分钟腹腔注射0、0.5或1.5 g/kg乙醇，但在测试日不注射乙醇或强化物进行测试。1.5 g/kg的乙醇损害了成年大鼠的空间学习能力，但未损害青春期大鼠，两个年龄段在非空间任务上均未受到乙醇损害。这些结果与Markwiese等人（1998年）报道的个体发育情况相反，可能反映了这两个任务在不同年龄阶段对前额叶皮层或其他应激敏感的前脑区域的不同激活。
