Arafa Mostafa A, Alkhouly Alaa, Youssef Manal E
Faculty of Medicine, King Khalid University, Abha, Saudi Arabia.
Paediatr Perinat Epidemiol. 2004 Jul;18(4):248-52. doi: 10.1111/j.1365-3016.2004.00564.x.
The influence of pregnancy spacing on preterm delivery (<37 weeks gestation) was examined in a group of mothers attending three Maternal and Child Health centres in three different districts in the city of Alexandria, Egypt between October 2001 and July 2002. All pregnant mothers attending the centres were interviewed or had their medical records reviewed. They were followed up until delivery and were questioned about current and past obstetric history and their medical history; their haemoglobin level was measured. The inter-pregnancy interval was calculated as the number of months between the delivery date of the women's last previous live infant and the date of the last menstrual period before the current pregnancy. There were 1202 pregnant women eligible for inclusion. The inter-pregnancy intervals were divided into five categories: <12, 12-36, 37-48, 49-60 and >60 months. We calculated the rates of preterm deliveries for each inter-pregnancy interval. Unadjusted odds ratios were estimated and stepwise logistic regression analysis was then used to adjust for all confounding factors. The rate of preterm delivery was 9.4%, and the lowest risk occurred in women who had an inter-pregnancy interval >60 months; 7.3% of those women gave birth to preterm infants. The rate of preterm delivery increased with increasing inter-pregnancy interval until 49-60 months; however, the association between inter-pregnancy interval and preterm delivery was not statistically significant whether using the crude or adjusted odds ratios.
2001年10月至2002年7月期间，在埃及亚历山大市三个不同区的三家妇幼保健中心，对一组孕妇进行了妊娠间隔对早产（妊娠<37周）影响的研究。所有到这些中心就诊的孕妇都接受了访谈或病历审查。对她们进行随访直至分娩，并询问其当前和既往的产科病史及病史；测量她们的血红蛋白水平。妊娠间隔的计算方法是该妇女上一个活产婴儿的出生日期与本次妊娠前末次月经日期之间的月数。共有1202名符合纳入标准的孕妇。妊娠间隔分为五类：<12、12 - 36、37 - 48、49 - 60和>60个月。我们计算了每个妊娠间隔的早产率。估计了未调整的比值比，然后采用逐步逻辑回归分析对所有混杂因素进行校正。早产率为9.4%，妊娠间隔>60个月的妇女早产风险最低；这些妇女中有7.3%分娩出早产儿。早产率随着妊娠间隔的增加而上升，直至49 - 60个月；然而，无论使用粗比值比还是校正后的比值比，妊娠间隔与早产之间的关联均无统计学意义。
