[Investigations about the influence of immune complexes on in vitro migration of human neutrophilic blood granulocytes (author's transl)].

We studied the influence of cell-free culture supernatants of human blood mononuclear cells exposed to precipitated immune complexes on the migration of polymorphnuclear leukocytes. During the first phase of incubation supernatants from apparently unaffected control cultures were found to stimulate the spontaneous and chemotactic migration (migration enhancing factor, chemotactic factor). In the further course mononuclear cells spontaneously produced a migration inhibitory activity. The presence of immune complexes increased the production of the neutrophil migration inhibitory activity and of the chemotactic factor. Considering our recently published results the experiments confirm the concept that immune complexe act on granulocyte migration in two ways: they induce a release of mediators from neutrophils as well as from mononuclear cells. Our present investigations deal with the question what type of cells-monocytes or lymphocytes-is responsible for this effect.