[Studies on the influence of immune complexes on the in-vitro-migration of human blood-granulocytes (author's transl)].

A high concentration of precipiated immune complexes inhibits the in vitro migration of human polymorphnuclear leucocytes. On the other side a low concentration of insoluble antigen-antibody complexes as well as soluble immune complexes were found to stimulate the migration. The immune complexes act indirectly on the migration of neutrophils by a nonspecific release of mediators from neutrophils. Since immune complexes may influence the migration of granulocytes, it is important in leucocyte migration tests used for evaluation of cellular immunity to avoid the presence of immune complexes.