类风湿关节炎患者血清对中性粒细胞迁移的抑制作用。
Inhibition of neutrophil migration by sera from patients with rheumatoid arthritis.
作者信息
Kemp A S, Roberts-Thomson P, Neoh S H, Brown S
出版信息
Clin Exp Immunol. 1979 Jun;36(3):423-9.
Abstract
Sera from patients with rheumatoid arthritis inhibited the migration of human neutrophils in 63% (twenty-two out of thirty-five) of the cases tested. The inhibition was not due to a toxic effect of the serum as it was reversed by a chemotactic stimulus. There was a strong correlation between the degree of inhibition of neutrophil migration and the amount of immune complexes present in the sera as determined by the C1q binding activity. It is suggested that the inhibition of neutrophil migration is due to the presence of circulating immune complexes, and that the capacity of immune complexes to inhibit neutrophil migration in vitro may also contribute to the accumulation of neutrophils at sites of immune complex formation in vivo.
摘要
类风湿性关节炎患者的血清在63%（35例中的22例）的测试病例中抑制了人类中性粒细胞的迁移。这种抑制并非由于血清的毒性作用，因为趋化刺激可使其逆转。中性粒细胞迁移的抑制程度与血清中通过C1q结合活性测定的免疫复合物量之间存在很强的相关性。有人提出，中性粒细胞迁移的抑制是由于循环免疫复合物的存在，并且免疫复合物在体外抑制中性粒细胞迁移的能力也可能有助于体内免疫复合物形成部位中性粒细胞的聚集。
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