Newmark Jonathan
Chemical Casualty Care, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010-5400, USA.
Semin Neurol. 2004 Jun;24(2):185-96. doi: 10.1055/s-2004-830906.
Nerve agents, the deadliest of the classical chemical warfare agents, primarily function as acetylcholinesterase inhibitors and cause a rapidly progressive cholinergic crisis. Because of the speed of onset of the syndrome, treatment must be rendered emergently and will most likely be performed by first responders. Neurologists should be familiar with the pathophysiology and treatment of syndromes caused by nerve agents, not only to assist with the hospital care of these patients but also to serve as resources to their local medical communities in preparation for chemical terrorism.
神经毒剂是最致命的传统化学战剂，主要作为乙酰胆碱酯酶抑制剂发挥作用，并引发迅速进展的胆碱能危象。由于该综合征发病迅速，必须立即进行治疗，且很可能由急救人员实施。神经科医生应熟悉神经毒剂所致综合征的病理生理学和治疗方法，不仅要协助对这些患者进行医院护理，还要作为当地医疗社区的资源，为应对化学恐怖主义做好准备。
