Kemppainen Barbara W, Urry Dan W, Swaim Steven F, Sartin Eva A, Gillette Robert L, Hinkle Sherri H, Coolman Shindok L, Luan Chi-Xiang, Xu Jie
Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Wound Repair Regen. 2004 Jul-Aug;12(4):453-60. doi: 10.1111/j.1067-1927.2004.12410.x.
A previous study showed that topical exposure to bioelastic-thromboxane synthetase inhibitor-matrix resulted in local tissue concentrations of thromboxane synthetase inhibitor sufficient for thromboxane synthetase inhibition. The objective of this research was to use an animal model to determine if a dressing having controlled release of thromboxane synthetase inhibitor (dazmegrel) could be used to prevent tissue breakdown over pressure points, i.e., lesion at the assistive device-skin interface. The animal model studies utilized the greyhound, a dog that has thin skin, angular conformation, limited body fat and is predisposed to pressure ulcers similar to those occurring in humans. The model uses a short-limb walking cast on one pelvic limb with the severity of the dermal pressure lesions induced over the medial malleolus controlled by the amount of padding in the cast and length of time the cast is in place. The bioelastic matrix loaded with dazmegrel provided protection from shearing and pressure skin injury over the medial malleolus, as evidenced by a decrease in epidermal abrasion/ulceration as measured with planimetry. Histopathologic evaluation of the skin over the medial malleolus indicated a protective function of the bioelastic matrix as measured as lower numbers of neutrophils, lymphocytes, and decreased collagen density compared to such numbers when no bioelastic matrix was present. These studies provided evidence that bioelastic-thromboxane sythetase inhibitor- matrix helps in preventing or reducing the severity of pressure lesions, e.g., assistive device-skin interface wounds.
先前的一项研究表明，局部暴露于生物弹性血栓素合成酶抑制剂基质会导致局部组织中血栓素合成酶抑制剂的浓度足以抑制血栓素合成酶。本研究的目的是使用动物模型来确定一种具有控释血栓素合成酶抑制剂（达美格雷）的敷料是否可用于预防压力点处的组织破损，即辅助装置与皮肤界面处的损伤。动物模型研究使用了灵缇犬，这种犬皮肤薄、体型呈角状、体脂有限，且易患与人类相似的压疮。该模型在一侧骨盆肢体上使用短肢行走石膏，通过石膏中的衬垫量和石膏放置时间来控制在内踝上方诱导的皮肤压力损伤的严重程度。载有达美格雷的生物弹性基质对内踝上方的剪切和压力性皮肤损伤起到了保护作用，这通过平面测量法测得的表皮擦伤/溃疡减少得以证明。对内踝上方皮肤的组织病理学评估表明，与不存在生物弹性基质时相比，生物弹性基质具有保护作用，表现为中性粒细胞、淋巴细胞数量减少以及胶原密度降低。这些研究提供了证据，表明生物弹性血栓素合成酶抑制剂基质有助于预防或减轻压力性损伤的严重程度，例如辅助装置与皮肤界面处的伤口。
