Muller Jacqueline E, Koen Liezl, Soraya Seedat, Emsley Robin A, Stein Daniel J
Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, Cape Town 7505, South Africa.
Curr Psychiatry Rep. 2004 Aug;6(4):255-61. doi: 10.1007/s11920-004-0074-0.
Anxiety symptoms and disorders have long been described in schizophrenia. This article reviews the epidemiology, phenomenology, and neurobiologic underpinnings of comorbid anxiety symptoms and disorders in schizophrenia. Recent literature was obtained by Medline searches using key words relating to schizophrenia and anxiety symptoms or disorders. There is some evidence that anxiety may be a core symptom dimension in schizophrenia, although further work is required. There is evidence that comorbid obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, and social anxiety disorder are all more common than expected by chance in schizophrenia, although additional work is needed to determine the mechanisms that underlie these associations and their clinical implications. In the interim, however, the data emphasize the importance of assessing and treating comorbid anxiety symptoms and disorders in schizophrenia.
焦虑症状和障碍在精神分裂症中早有描述。本文综述了精神分裂症中共病焦虑症状和障碍的流行病学、现象学及神经生物学基础。通过使用与精神分裂症及焦虑症状或障碍相关的关键词在医学文献数据库（Medline）中检索获取近期文献。有证据表明焦虑可能是精神分裂症的一个核心症状维度，不过仍需进一步研究。有证据显示，共病的强迫症、惊恐障碍、创伤后应激障碍及社交焦虑障碍在精神分裂症中的发生率均高于偶然预期，尽管还需要更多研究来确定这些关联背后的机制及其临床意义。然而在此期间，这些数据强调了评估和治疗精神分裂症中共病焦虑症状和障碍的重要性。
