Brophy Peter J
Centre for Neuroscience Research, University of Edinburgh, EH9 1QH, United Kingdom.
Neuron. 2004 Jul 22;43(2):154-5. doi: 10.1016/j.neuron.2004.07.005.
Axons need to be above a minimum size before they can be ensheathed by myelin-forming glia. But it has generally been assumed that the axonal signals that initiate myelination, whatever they are, would act similarly in both the CNS and the PNS. The surprising finding of Chan et al. in this issue of Neuron is that NGF can act as a regulator of ensheathment but that it has opposite effects on CNS and PNS axons.
轴突需要达到最小尺寸才能被形成髓鞘的神经胶质细胞包裹。但一般认为，启动髓鞘形成的轴突信号，无论其为何种信号，在中枢神经系统（CNS）和外周神经系统（PNS）中的作用方式相似。陈等人在本期《神经元》杂志上的惊人发现是，神经生长因子（NGF）可作为包裹过程的调节因子，但其对中枢神经系统和外周神经系统轴突的作用相反。
