对比中枢神经系统和周围神经系统对轴突损伤的反应。

Contrasting the glial response to axon injury in the central and peripheral nervous systems.

机构信息

Department of Neurobiology, Stanford University, Stanford, CA 94110, USA.

出版信息

Dev Cell. 2014 Jan 13;28(1):7-17. doi: 10.1016/j.devcel.2013.12.002.

DOI:10.1016/j.devcel.2013.12.002

Abstract

Enabling axon regeneration after central nervous system (CNS) injury remains a major challenge in neurobiology. One of the major differences between the injured peripheral nervous system (PNS) and CNS is the pro- and antiregenerative responses of their glial cell populations. In addition to intrinsic qualities of the neurons themselves, glial-driven changes to the neural environment have a significant impact on regenerative outcome. This Review presents a comparison of the glial response to injury between the CNS and PNS and highlights features of the PNS glial response that, with continued study, might reveal long-sought-after keys to achieving CNS repair.

摘要

中枢神经系统（CNS）损伤后的轴突再生仍然是神经生物学的主要挑战之一。受伤的周围神经系统（PNS）和中枢神经系统之间的主要区别之一是其神经胶质细胞群体的促再生和抗再生反应。除了神经元本身的内在特性外，神经胶质细胞驱动的神经环境变化对再生结果有重大影响。本综述比较了 CNS 和 PNS 中胶质细胞对损伤的反应，并强调了 PNS 胶质细胞反应的特征，随着进一步的研究，这些特征可能揭示长期以来寻求实现 CNS 修复的关键。