酶的定位和复合物形成在高尔基体中聚糖组装过程中的作用。

The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus.

作者信息

de Graffenried Christopher L, Bertozzi Carolyn R

机构信息

Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.

出版信息

Curr Opin Cell Biol. 2004 Aug;16(4):356-63. doi: 10.1016/j.ceb.2004.06.007.

DOI:10.1016/j.ceb.2004.06.007

PMID:15261667

Abstract

Cell surface glycans govern numerous cell-cell interactions are therefore key determinants of multicellular biology. They originate from biosynthetic pathways comprising an assembly line of glycosyltransferases within the Golgi compartment. Although the mechanisms of Golgi enzyme localisation are still under debate, the distribution of these enzymes among the Golgi cisternae can dictate the overall structures produced by the cell. Fine-tuning of glycan biosynthetic pathways is further accomplished by specific associations among glycosyltransferases. Together, localisation and association govern the assembly of complex glycans and thereby regulate interactions at the cell surface.

摘要

细胞表面聚糖控制着众多细胞间相互作用，因此是多细胞生物学的关键决定因素。它们源自生物合成途径，该途径由高尔基体区室内糖基转移酶的装配线组成。尽管高尔基体酶定位的机制仍在争论中，但这些酶在高尔基体潴泡间的分布可决定细胞产生的整体结构。糖基转移酶之间的特定关联进一步实现了聚糖生物合成途径的微调。定位和关联共同控制复杂聚糖的组装，从而调节细胞表面的相互作用。