神经元中依赖微管的运输：迈向理解调节、功能及功能障碍的步骤

Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction.

作者信息

Guzik Brian W, Goldstein Lawrence S B

机构信息

Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093-0683, USA.

出版信息

Curr Opin Cell Biol. 2004 Aug;16(4):443-50. doi: 10.1016/j.ceb.2004.06.002.

DOI:10.1016/j.ceb.2004.06.002

PMID:15261678

Abstract

Intracellular transport by microtubule-dependent motors is crucial for neuronal survival and function. Recent advances reveal novel strategies for the regulation of transport and the attachment of motors to cargoes. Current findings also illustrate the importance of directed transport in neuronal biology, including microtubule-motor-dependent transduction of neurotrophic signals and axonal damage signal complexes. Furthermore, recent data implicating the dysfunction of microtubule-dependent transport in the cause and development of several neurodegenerative diseases provides evidence for the vital role of transport in neuronal and organismal function.

摘要

由微管依赖型马达进行的细胞内运输对于神经元的存活和功能至关重要。最近的进展揭示了调节运输以及马达与货物附着的新策略。目前的研究结果还阐明了定向运输在神经元生物学中的重要性，包括神经营养信号和轴突损伤信号复合物的微管-马达依赖性转导。此外，最近的数据表明微管依赖型运输功能障碍与几种神经退行性疾病的发生和发展有关，这为运输在神经元和机体功能中的重要作用提供了证据。