Lu B, Gonzalez A, Massion P P, Shyr Y, Shaktour B, Carbone D P, Hallahan D E
Department of Radiation Oncology, Vanderbilt Ingram, Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Br J Cancer. 2004 Aug 2;91(3):537-40. doi: 10.1038/sj.bjc.6602027.
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.
生存素抑制细胞凋亡并促进有丝分裂。我们确定了生存素的核定位或胞质定位是否可预测48例接受手术切除的非小细胞肺癌（NSCLC）患者的生存情况。生存素有核染色的患者生存情况明显更差（相对风险：3.9，P = 0.02）。因此，生存素可能是非小细胞肺癌的一种生物标志物。
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