[白细胞介素-1β和肿瘤坏死因子-α在慢性前列腺炎前列腺分泌物中的临床评估]

[Clinical evaluation of IL-1beta and TNF-alpha in prostatic secretions for chronic prostatitis].

作者信息

Yang Jinyi, Ye Lin, Jiang Hongbo, Zhou Jie, Hou Xu, Deng Xin

机构信息

Department of Urology, Friendship Hospital of Dalian, Dalian, Liaoning 116001, China.

出版信息

Zhonghua Nan Ke Xue. 2004 Jun;10(6):449-50, 454.

PMID:15267213

Abstract

OBJECTIVE

To determine the clinical significance of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha( TNF-alpha) in expressed prostatic secretions(EPS) for chronic prostatitis.

METHODS

Prostatic secretions IL-1beta and TNF-alpha were evaluated for 34 patients with chronic prostatitis, 10 with asymptomatic inflammatory prostatitis, 12 with benign prostatic hyperplasia (BPH) and 8 health controls by enzyme-linked immunosorbent assay (ELISA).

RESULTS

IL-1beta and TNF-alpha levels in EPS in the patients of chronic prostatitis with WBC > or = 10/HP and asymptomatic inflammatory prostatitis were obviously higher than those of chronic prostatitis with WBC < 10/HP, BPH and health controls, (P < 0.05 and P < 0.02). There was a correlation between IL-1beta and TNF-alpha (P < 0.003) but none between WBC and IL-1beta or TNF-alpha.

CONCLUSION

Cytokines are frequently elevated in EPS in men of chronic prostatitis with high WBC and asymptomatic inflammatory prostatitis, which provides a novel means different from traditional methods based on WBC for the identification of men with chronic prostatitis.

摘要

目的

确定白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）在慢性前列腺炎患者前列腺分泌物（EPS）中的临床意义。

方法

采用酶联免疫吸附测定（ELISA）法对34例慢性前列腺炎患者、10例无症状性炎症性前列腺炎患者、12例良性前列腺增生（BPH）患者及8例健康对照者的前列腺分泌物IL-1β和TNF-α进行检测。

结果

白细胞≥10/HP的慢性前列腺炎患者及无症状性炎症性前列腺炎患者EPS中的IL-1β和TNF-α水平明显高于白细胞＜10/HP的慢性前列腺炎患者、BPH患者及健康对照者（P＜0.05和P＜0.02）。IL-1β与TNF-α之间存在相关性（P＜0.003），但白细胞与IL-1β或TNF-α之间无相关性。