Frost P A, Hubbard G B, Dammann M J, Snider C L, Moore C M, Hodara V L, Giavedoni L D, Rohwer R, Mahaney M C, Butler T M, Cummins L B, McDonald T J, Nathanielsz P W, Schlabritz-Loutsevitch N E
Department of Comparative Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA.
J Med Primatol. 2004 Aug;33(4):197-213. doi: 10.1111/j.1600-0684.2004.00071.x.
Over 23 months, zinc toxicosis was diagnosed in 35 baboons aged 5-12 months in one galvanized metal and concrete cage complex with conditions that led to excessive exposure to environmental zinc. Clinical signs included reduced pigmentation of hair, skin, and mucous membranes (whiteness), alopecia, dehydration, emaciation, cachexia, dermatitis, diarrhea and, in six cases, severe gangrenous dermatitis of extremities. The syndrome was characterized by pancytopenia, elevated zinc and low copper serum concentrations, low vitamin D and bone-specific alkaline phosphatase levels, and atypical myelomonocytic proliferation of bone marrow. This syndrome emphasizes the importance of proper husbandry and cage design and indicates the potential of infant baboons as a model to study the effects of excessive zinc on development. This is the first report describing the epidemiologic and clinical presentation of zinc toxicosis in infant baboons in captivity.
在23个多月的时间里，在一个镀锌金属和混凝土笼舍建筑群中，对35只5至12个月大的狒狒诊断出锌中毒，该笼舍的环境导致狒狒过度接触环境中的锌。临床症状包括毛发、皮肤和黏膜色素沉着减少（变白）、脱发、脱水、消瘦、恶病质、皮炎、腹泻，6例出现四肢严重坏疽性皮炎。该综合征的特征为全血细胞减少、血清锌升高和铜浓度降低、维生素D和骨特异性碱性磷酸酶水平降低，以及骨髓非典型髓单核细胞增殖。该综合征强调了适当饲养管理和笼舍设计的重要性，并表明幼年狒狒作为研究过量锌对发育影响模型的潜力。这是首份描述圈养幼年狒狒锌中毒流行病学和临床表现的报告。
