Kempermann Gerd, Jessberger Sebastian, Steiner Barbara, Kronenberg Golo
VolkswagenStiftung Research Group, Department of Experimental Neurology, Charité University Medicine Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany.
Trends Neurosci. 2004 Aug;27(8):447-52. doi: 10.1016/j.tins.2004.05.013.
Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.
成体海马神经发生起源于成体齿状回中的前体细胞，并产生新的颗粒细胞神经元。我们提出了一个在这两个固定点之间发生的发育模型，并确定了几个发育里程碑。从具有星形胶质细胞特性的推测为双能放射状胶质样干细胞（1型细胞）开始，发育至少经过两个阶段，即扩增谱系确定的祖细胞（2型和3型细胞），发展为早期有丝分裂后神经元和成熟神经元。新神经元被招募进入功能状态的选择过程以及其他调节影响对发育的不同阶段有不同的影响。
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