Boroday Natalya, Klyushin Dmitriy, Petunin Yuriy, Andrushkiw Roman
R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine.
Exp Oncol. 2004 Jun;26(2):158-60.
To study from the point of view of statistical and geometrical theory of pattern recognition, the peculiarities of the distribution of optical density of DNA in the interphase nuclei of mammary buccal epithelium upon pathology.
Cytogenetic investigation of buccal smears and computer-based image analysis were used.
It is shown that in malignant neoplasms of the mammary glands compared with its values in benign, the optical density of DNA in the nuclei of buccal epithelium increase in a range from 0.15 to 0.30 conventional units. The sensitivity of that criterium varied from 80.5% to 96.8%, and specificity was 92.3%.
The method proposed may be recommended as an additional one for improvement of the diagnosis of mammary pathologies.
从模式识别的统计学和几何学理论角度研究乳腺颊黏膜上皮细胞间期核中DNA光密度在病理状态下的分布特点。
采用颊黏膜涂片的细胞遗传学研究和基于计算机的图像分析。
结果表明，与良性乳腺肿瘤相比，在恶性乳腺肿瘤中，颊黏膜上皮细胞核中DNA的光密度增加了0.15至0.30个传统单位。该标准的敏感性在80.5%至96.8%之间，特异性为92.3%。
所提出的方法可作为一种辅助方法推荐用于改善乳腺疾病的诊断。
