与克罗恩病相关的同步性回肠和结肠腺癌：一例报告，重点关注基因改变和致癌机制
Synchronous ileal and colonic adenocarcinomas associated with Crohn's disease: report of a case with a focus on genetic alterations and carcinogenesis.
作者信息
Baisse B, Fontolliet C, Bian Y S, Vuilleumier H, Benhattar J
机构信息
Institute of Pathology, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.
出版信息
J Clin Pathol. 2004 Aug;57(8):885-7. doi: 10.1136/jcp.2003.014811.
Abstract
Patients with Crohn's disease have an increased risk of developing intestinal tumours. However, the carcinogenic mechanisms remain poorly understood. To address this question, this report describes an unusual case of Crohn's disease complicated by synchronous small intestinal and colonic adenocarcinomas. Genetic events in both the tumours and their adjacent mucosae were evaluated and the tumorigenesis of these cancers is discussed.
摘要
克罗恩病患者发生肠道肿瘤的风险增加。然而，致癌机制仍知之甚少。为解决这一问题，本报告描述了一例罕见的克罗恩病病例，该病例并发同步性小肠和结肠腺癌。对肿瘤及其相邻黏膜中的基因事件进行了评估，并讨论了这些癌症的肿瘤发生过程。
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