Boffetta Paolo, Soutar Anne, Cherrie John W, Granath Fredrik, Andersen Aage, Anttila Ahti, Blettner Maria, Gaborieau Valerie, Klug Stefanie J, Langard Sverre, Luce Daniele, Merletti Franco, Miller Brian, Mirabelli Dario, Pukkala Eero, Adami Hans-Olov, Weiderpass Elisabete
International Agency for Research on Cancer, Lyon, France.
Cancer Causes Control. 2004 Sep;15(7):697-706. doi: 10.1023/B:CACO.0000036188.23970.22.
To assess the risk of lung cancer mortality related to occupational exposure to titanium dioxide (TiO2).
A mortality follow-up study of 15,017 workers (14,331 men) employed in 11 factories producing TiO2 in Europe. Exposure to TiO2 dust was reconstructed for each occupational title; exposure estimates were linked with the occupational history. Observed mortality was compared with national rates, and internal comparisons were based on multivariate Cox regression analysis.
The cohort contributed 371,067 person-years of observation (3.3% were lost to follow-up and 0.7% emigrated). 2652 cohort members died during the follow-up, yielding standardized mortality ratios (SMRs) of 0.87 (95% confidence interval [CI] 0.83-0.90) among men and 0.58 (95% CI 0.40-0.82) among women. Among men, the SMR of lung cancer was significantly increased (1.23, 95% CI 1.10-1.38); however, mortality from lung cancer did not increase with duration of employment or estimated cumulative exposure to TiO2 dust. Data on smoking were available for over one third of cohort members. In three countries, the prevalence of smokers was higher among cohort members compared to the national populations.
The results of the study do not suggest a carcinogenic effect of TiO2 dust on the human lung.
评估职业性接触二氧化钛（TiO₂）与肺癌死亡风险之间的关系。
对欧洲11家生产TiO₂的工厂中雇佣的15017名工人（14331名男性）进行死亡率随访研究。针对每个职业头衔重建了TiO₂粉尘暴露情况；暴露估计值与职业史相关联。将观察到的死亡率与全国死亡率进行比较，并基于多变量Cox回归分析进行内部比较。
该队列贡献了371067人年的观察时间（3.3%的人失访，0.7%的人移民）。在随访期间，2652名队列成员死亡，男性的标准化死亡比（SMR）为0.87（95%置信区间[CI]0.83 - 0.90），女性为0.58（95%CI 0.40 - 0.82）。在男性中，肺癌的SMR显著升高（1.23，95%CI 1.10 - 1.38）；然而，肺癌死亡率并未随就业时长或估计的TiO₂粉尘累积暴露量增加。超过三分之一的队列成员有吸烟数据。在三个国家，队列成员中的吸烟者患病率高于全国人口。
该研究结果并未表明TiO₂粉尘对人类肺部有致癌作用。
