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聚-N-乙酰葡糖胺衍生的快速止血创伤敷料在严重/致命性猪出血创伤模型中的应用。

Application of the poly-N-acetyl glucosamine-derived rapid deployment hemostat trauma dressing in severe/lethal Swine hemorrhage trauma models.

作者信息

Connolly Raymond J

机构信息

Department of Surgery, New England Medical Center, Boston, Massachusetts 02111, USA.

出版信息

J Trauma. 2004 Jul;57(1 Suppl):S26-8. doi: 10.1097/01.ta.0000136746.97192.b2.

DOI:10.1097/01.ta.0000136746.97192.b2
PMID:15280747
Abstract

BACKGROUND

The Rapid Deployment Hemostat (RDH) Bandage was developed for the rapid control of bleeding caused by trauma.

METHODS

An extremity wound involving skin, muscle, bone, and femoral arterial injury and a 1-cm vertical incision in the abdominal aorta in swine were studied to compare the RDH Bandage, a fibrin sealant dressing and gauze to restore hemostasis. The total blood loss was determined and the survival of animals was measured.

RESULTS

In the extremity injury model, the RDH Bandage reduced blood loss by 63% compared with the gauze control. In the aorta arterial incision model, the RDH Bandage required a significantly lower compression time to control bleeding compared with gauze and TachoComb. The RDH Bandage was able to stop bleeding from this injury in 100% of the tests.

CONCLUSION

The RDH Bandage was superior to a commercially available fibrin bandage in controlling hemorrhage, decreasing blood loss, and increasing survival.

摘要

背景

快速部署止血绷带(RDH绷带)是为快速控制创伤引起的出血而研发的。

方法

研究了猪的涉及皮肤、肌肉、骨骼和股动脉损伤的肢体伤口以及腹主动脉上1厘米的垂直切口,以比较RDH绷带、纤维蛋白密封剂敷料和纱布恢复止血的效果。测定总失血量并测量动物的存活率。

结果

在肢体损伤模型中,与纱布对照相比,RDH绷带使失血量减少了63%。在主动脉动脉切口模型中,与纱布和速即纱相比,RDH绷带控制出血所需的压迫时间显著更短。在100%的测试中,RDH绷带能够止住这种损伤的出血。

结论

在控制出血、减少失血量和提高存活率方面,RDH绷带优于市售纤维蛋白绷带。

相似文献

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Application of the poly-N-acetyl glucosamine-derived rapid deployment hemostat trauma dressing in severe/lethal Swine hemorrhage trauma models.聚-N-乙酰葡糖胺衍生的快速止血创伤敷料在严重/致命性猪出血创伤模型中的应用。
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引用本文的文献

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Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding.生物材料与先进技术在出血止血管理中的应用
Adv Mater. 2018 Jan;30(4). doi: 10.1002/adma.201700859. Epub 2017 Nov 22.
2
GNPs-CS/KGM as hemostatic first aid wound dressing with antibiotic effect: in vitro and in vivo study.载有万古霉素的壳聚糖/明胶海绵作为具有抗生素效果的止血急救创伤敷料:体外和体内研究。
PLoS One. 2013 Jul 16;8(7):e66890. doi: 10.1371/journal.pone.0066890. Print 2013.
3
Poly-N-acetyl glucosamine gel matrix as a non-viral delivery vector for DNA-based vaccination.
聚-N-乙酰葡糖胺水凝胶基质作为基于 DNA 的疫苗接种的非病毒递送载体。
Anticancer Res. 2010 Oct;30(10):3889-94.