聚-N-乙酰葡糖胺衍生的快速止血创伤敷料在严重/致命性猪出血创伤模型中的应用。
Application of the poly-N-acetyl glucosamine-derived rapid deployment hemostat trauma dressing in severe/lethal Swine hemorrhage trauma models.
作者信息
Connolly Raymond J
机构信息
Department of Surgery, New England Medical Center, Boston, Massachusetts 02111, USA.
出版信息
J Trauma. 2004 Jul;57(1 Suppl):S26-8. doi: 10.1097/01.ta.0000136746.97192.b2.
BACKGROUND
The Rapid Deployment Hemostat (RDH) Bandage was developed for the rapid control of bleeding caused by trauma.
METHODS
An extremity wound involving skin, muscle, bone, and femoral arterial injury and a 1-cm vertical incision in the abdominal aorta in swine were studied to compare the RDH Bandage, a fibrin sealant dressing and gauze to restore hemostasis. The total blood loss was determined and the survival of animals was measured.
RESULTS
In the extremity injury model, the RDH Bandage reduced blood loss by 63% compared with the gauze control. In the aorta arterial incision model, the RDH Bandage required a significantly lower compression time to control bleeding compared with gauze and TachoComb. The RDH Bandage was able to stop bleeding from this injury in 100% of the tests.
CONCLUSION
The RDH Bandage was superior to a commercially available fibrin bandage in controlling hemorrhage, decreasing blood loss, and increasing survival.
背景
快速部署止血绷带（RDH绷带）是为快速控制创伤引起的出血而研发的。
方法
研究了猪的涉及皮肤、肌肉、骨骼和股动脉损伤的肢体伤口以及腹主动脉上1厘米的垂直切口，以比较RDH绷带、纤维蛋白密封剂敷料和纱布恢复止血的效果。测定总失血量并测量动物的存活率。
结果
在肢体损伤模型中，与纱布对照相比，RDH绷带使失血量减少了63%。在主动脉动脉切口模型中，与纱布和速即纱相比，RDH绷带控制出血所需的压迫时间显著更短。在100%的测试中，RDH绷带能够止住这种损伤的出血。
结论
在控制出血、减少失血量和提高存活率方面，RDH绷带优于市售纤维蛋白绷带。
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