Schwaitzberg Steven D, Chan Michele W, Cole David J, Read Marjorie, Nichols Timothy, Bellinger David, Connolly Raymond J
Department of Surgery, New England Medical Center, Boston, Massachusetts 02111, USA.
J Trauma. 2004 Jul;57(1 Suppl):S29-32. doi: 10.1097/01.ta.0000136747.35311.60.
The hemostatic quality of the poly-N-acetyl glucosamine (p-GlcNAc) patch was compared with a fibrin sealant, fibrin bandage, and cellulose patch.
A 2 x 2-cm capsular strip to a depth of 3 mm of the swine spleen was used as a source of bleeding. Splenic lacerations were created in hemophilia B dogs and treated with p-GlcNAc and Surgicel. Wounds were created in rabbits and treated with p-GlcNAc at 37degreesC and after keeping body core temperature at 29degreesC.
Poly-N-acetyl glucosamine was able to achieve hemostasis with greater efficacy than either of the fibrin-based bandages. In the hemophilia B dog study, p-GlcNAc significantly outperformed Surgicel, with p-GlcNAc achieving hemostasis in 75% of the treated wounds compared with 17% for the cellulose patch. The hypothermia study demonstrated that p-GlcNAc is equally effective at 29degreesC and at 37degreesC.
Poly-N-acetyl glucosamine was effective at controlling bleeding in animals with experimentally induced or genetic coagulopathic disorders.
将聚-N-乙酰葡糖胺（p-GlcNAc）贴片的止血性能与纤维蛋白密封剂、纤维蛋白绷带和纤维素贴片进行比较。
使用猪脾脏2×2厘米、深度3毫米的囊状条带作为出血源。在乙型血友病犬身上制造脾裂伤，并用p-GlcNAc和外科用纤维素进行治疗。在兔子身上制造伤口，并在37℃以及将核心体温维持在29℃后用p-GlcNAc进行治疗。
聚-N-乙酰葡糖胺实现止血的效果比任何一种纤维蛋白基绷带都更好。在乙型血友病犬的研究中，p-GlcNAc的表现明显优于外科用纤维素，p-GlcNAc在75%的治疗伤口中实现了止血，而纤维素贴片为17%。低温研究表明，p-GlcNAc在29℃和37℃时同样有效。
聚-N-乙酰葡糖胺在控制实验诱导或遗传性凝血病动物的出血方面有效。
