Skrzycki Michał, Czeczot Hanna
Katedra i Zakład Biochemii Akademii Medycznej w Warszawie.
Postepy Hig Med Dosw (Online). 2004 Jul 24;58:301-11.
EC-SOD catalyzes the dismutation of superoxide radical to hydrogen peroxide and oxygen in the interstitial spaces of tissues and in extracellular fluids (plasma, lymph, and synovial fluid). It eliminates superoxide radicals from the cell environment and prevents the formation of reactive oxygen species and their derivatives. EC-SOD is a secretory, tetrameric glycoprotein containing copper and zinc, with a high affinity to certain glycosaminoglycans, such as heparin and heparan sulfate. It plays an important role in maintaining vascular tone, lung function, and the metabolism of NO, and in the pathology of such diseases as atherosclerosis, diabetes, and arthritis. This paper describes EC-SOD structure, function in tissues, and possibilities of therapy with application of this enzyme.
细胞外超氧化物歧化酶（EC-SOD）催化超氧阴离子自由基在组织间隙和细胞外液（血浆、淋巴液和滑液）中歧化为过氧化氢和氧气。它从细胞环境中清除超氧阴离子自由基，防止活性氧及其衍生物的形成。EC-SOD是一种分泌性的四聚体糖蛋白，含有铜和锌，对某些糖胺聚糖如肝素和硫酸乙酰肝素具有高亲和力。它在维持血管张力、肺功能以及一氧化氮代谢方面发挥重要作用，并且在动脉粥样硬化、糖尿病和关节炎等疾病的病理过程中也有作用。本文描述了EC-SOD的结构、在组织中的功能以及应用该酶进行治疗的可能性。
