Carroll Christie L, Feldman Steven R, Camacho Fabian T, Manuel Janeen C, Balkrishnan Rajesh
Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, NC 27104, USA.
J Am Acad Dermatol. 2004 Aug;51(2):212-6. doi: 10.1016/j.jaad.2004.01.052.
Medication nonadherence is common throughout medicine, and research into this area is increasing; however, knowledge about topical medication adherence is limited.
A total of 30 patients were enrolled in a clinical trial for psoriasis and followed up for 8 weeks using 3 methods of adherence monitoring: electronic monitoring caps; medication logs; and medication usage by weight.
Adherence rates calculated from the medication logs and medication weights were consistently higher than those of the electronic monitors (P <.05). Electronically measured adherence rates declined from 84.6% to 51% during the 8-week study (P <.0001). Female sex and increasing age by 1 year predicted improved adherence of 5% and 0.8%, respectively (P <.0001). The number of treatment gaps increased from the first half to the last half of the study, and weekend days were overrepresented in treatment gaps.
Medication logs and weights do not ensure medication adherence to topical therapy. Electronic monitoring allows a more precise method of adherence measurement.
药物治疗不依从在整个医学领域都很常见，并且对该领域的研究正在增加；然而，关于局部用药依从性的知识是有限的。
共有30名银屑病患者参加了一项临床试验，并使用3种依从性监测方法进行了8周的随访：电子监测帽；用药记录；以及按重量计算的用药量。
根据用药记录和用药重量计算出的依从率始终高于电子监测器的依从率（P<.05）。在为期8周的研究中，电子测量的依从率从84.6%下降到51%（P<.0001）。女性性别和年龄每增加1岁分别预示着依从性提高5%和0.8%（P<.0001）。治疗间隔的数量从研究的前半段到后半段有所增加，并且周末在治疗间隔中占比过高。
用药记录和重量并不能确保局部治疗的药物依从性。电子监测提供了一种更精确的依从性测量方法。
