通过钯交叉偶联合成新型N-芳基和N-杂芳基磺酰胺
Novel N-aryl and N-heteroaryl sulfamide synthesis via palladium cross coupling.
作者信息
Alcaraz Lilian, Bennion Colin, Morris James, Meghani Premji, Thom Stephen M
机构信息
Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, LE11 5RH, United Kingdom.
出版信息
Org Lett. 2004 Aug 5;6(16):2705-8. doi: 10.1021/ol049091l.
PMID:15281749
Abstract
A novel and efficient synthesis of N-aryl and N-heteroaryl sulfamides via an intermolecular palladium-catalyzed coupling process has been developed. The reactions proceeded with good to excellent yields and were tolerant of a wide range of functional groups. [reaction: see text]
摘要
通过分子间钯催化偶联过程，已开发出一种新颖且高效的N-芳基和N-杂芳基磺酰胺的合成方法。反应以良好至优异的产率进行，并且对多种官能团具有耐受性。[反应：见正文]
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