通过钯催化偶联过程高效合成菲啶酮衍生物。
Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process.
作者信息
Furuta Takumi, Kitamura Yuki, Hashimoto Ayano, Fujii Satoshi, Tanaka Kiyoshi, Kan Toshiyuki
机构信息
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
出版信息
Org Lett. 2007 Jan 18;9(2):183-6. doi: 10.1021/ol062599z.
A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives. [reaction: see text].
开发了一种钯介导的多米诺反应，以方便地合成菲啶酮衍生物。膦配体1强烈促进多米诺过程，该过程包括芳基-芳基偶联和C-N键形成以及脱酰胺反应。该反应对多种底物的通用性和适用性使其对生物活性衍生物的开发很有用。[反应：见正文]
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