Matsugi Masato, Curran Dennis P
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Org Lett. 2004 Aug 5;6(16):2717-20. doi: 10.1021/ol049040o.
Fluorous-tagged compounds can rapidly be separated from organic (non-tagged) compounds by the new separation technique of reverse fluorous solid-phase extraction (r-fspe). In a reversal of the roles of solid and liquid phases in standard fluorous spe, a mixture is charged to a polar solid phase (standard silica gel) and then eluted with a fluorous solvent or solvent mixture. The organic components of the mixture are retained, while the fluorous components pass. [structure: see text]
含氟标记化合物可通过反向含氟固相萃取（r-fspe）这一新分离技术，快速从有机（未标记）化合物中分离出来。在标准含氟固相萃取中，固相和液相的作用发生了反转，将混合物加载到极性固相（标准硅胶）上，然后用含氟溶剂或溶剂混合物洗脱。混合物中的有机成分被保留，而含氟成分则通过。[结构：见原文]
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