Yu Marvin S, Curran Dennis P, Nagashima Tadamichi
Fluorous Technologies, Inc., 970 William Pitt Way, Pittsburgh, PA 15238, USA.
Org Lett. 2005 Aug 18;7(17):3677-80. doi: 10.1021/ol051170p.
Low partition coefficients of fluorous components have been a persistent problem in liquid-liquid separations using perfluoroalkanes as the fluorous phase. Solvent tuning of both the nonfluorous and the fluorous phase dramatically enhances the partitioning of light or polar fluorous molecules into the fluorous liquid phase, while minimally effecting partition coefficients of nonfluorous molecules. These findings suggest an expanded scope for liquid-based separations in fluorous biphasic catalysis, fluorous-tagged reagents, fluorous-supported oligomer synthesis, and related areas. [reaction: see text]
在使用全氟烷烃作为氟相的液-液分离中，含氟组分的低分配系数一直是个棘手的问题。对非氟相和氟相进行溶剂调节，能显著增强轻质或极性含氟分子在氟液相中的分配，同时对非氟分子的分配系数影响极小。这些发现表明，在氟两相催化、氟标记试剂、氟负载低聚物合成及相关领域中，基于液体的分离范围得以扩大。[反应：见正文]
