蛋白质设计与生物自组装的新范式
A New Paradigm for Protein Design and Biological Self-Assembly.
作者信息
Akçay Gizem, Kumar Krishna
机构信息
Department of Chemistry, Tufts University, Medford, MA 02155.
出版信息
J Fluor Chem. 2009 Dec 1;130(12):1178-1182. doi: 10.1016/j.jfluchem.2009.09.002.
Abstract
Very few molecules with biological origins contain the element fluorine. Nature's inability to incorporate fluorine into biomolecules is related to the low concentration of free fluoride in sea and surface water. However, judicious introduction of fluorine into proteins, nucleic acids, lipids and carbohydrates has allowed mechanistic scrutiny of enzyme catalysis, control of protein oligomerization in membranes, clustered display of ligands on surfaces of living cells, and in increasing the protease stability of protein and peptide therapeutics.
摘要
具有生物来源的分子中含氟的极少。自然界无法将氟纳入生物分子与海水中和地表水中游离氟的低浓度有关。然而，将氟明智地引入蛋白质、核酸、脂质和碳水化合物中，有助于对酶催化进行机理研究、控制膜中蛋白质的寡聚化、在活细胞表面成簇展示配体，以及提高蛋白质和肽类治疗药物的蛋白酶稳定性。
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