氨基酸N-羧基酸酐：在水溶液中表现为磷酸激活剂的活性肽单体。
Amino acid N-carboxyanhydrides: activated peptide monomers behaving as phosphate-activating agents in aqueous solution.
作者信息
Biron Jean-Philippe, Pascal Robert
机构信息
Organisation Moléculaire Evolution et Matériaux Fluorés UMR 5073 - CC 017, Département de Chimie, Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France.
出版信息
J Am Chem Soc. 2004 Aug 4;126(30):9198-9. doi: 10.1021/ja048189s.
PMID:15281806
Abstract
The hydrolysis of valine N-carboxyanhydride (NCA) in aqueous phosphate buffers was shown to proceed through nucleophilic catalysis via an aminoacyl phosphate intermediate that displays phosphorylating capabilities through a potentially prebiotic process that simulates modern biochemical metabolic pathways.
摘要
缬氨酸N-羧基环内酸酐（NCA）在磷酸盐水溶液中的水解过程表明，它是通过一个氨基酰磷酸中间体进行亲核催化的，该中间体通过一个模拟现代生物化学代谢途径的潜在益生元过程展现出磷酸化能力。
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