Leman Luke J, Orgel Leslie E, Ghadiri M Reza
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
J Am Chem Soc. 2006 Jan 11;128(1):20-1. doi: 10.1021/ja056036e.
Carbonyl sulfide (COS), a component of volcanic gas emissions and interstellar gas clouds, is shown to be an efficient condensing agent in the context of phosphate chemistry in aqueous solutions. We report that high-energy aminoacyl-phosphate anhydrides and aminoacyl adenylates are generated in solutions containing amino acids, COS, and the corresponding phosphate molecule. We further show that the mixed anhydrides of amino acids and inorganic phosphate are phosphorylating agents, producing pyrophosphate in better than 30% yield in the presence of Ca2+ precipitates. The amino acid dependent activations of phosphate reported here, which occur in parallel with the production of peptides, suggest that these two reactions may have shared a common intermediate on the prebiotic Earth.
羰基硫（COS）是火山气体排放物和星际气体云的组成成分，在水溶液中的磷酸盐化学环境中，它被证明是一种高效的缩合剂。我们报告称，在含有氨基酸、COS和相应磷酸盐分子的溶液中会生成高能氨酰基 - 磷酸酐和氨酰基腺苷酸。我们进一步表明，氨基酸和无机磷酸盐的混合酸酐是磷酸化试剂，在存在Ca2+沉淀的情况下，焦磷酸的产率高于30%。本文报道的依赖于氨基酸的磷酸盐活化反应与肽的生成同时发生，这表明这两个反应在早期地球上可能有一个共同的中间体。
