Liu Ziwei, Rossi Jean-Christophe, Pascal Robert
UMR5247, CNRS-University of Montpellier-ENSCM, Place E. Bataillon, 34095 Montpellier CEDEX 5, France.
MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Life (Basel). 2019 Mar 3;9(1):26. doi: 10.3390/life9010026.
The very specific thermodynamic instability and kinetic stability of phosphate esters and anhydrides impart them invaluable properties in living organisms in which highly efficient enzyme catalysts compensate for their low intrinsic reactivity. Considering their role in protein biosynthesis, these properties raise a paradox about early stages: How could these species be selected in the absence of enzymes? This review is aimed at demonstrating that considering mixed anhydrides or other species more reactive than esters and anhydrides can help in solving the paradox. The consequences of this approach for chemical evolution and early stages of life are analysed.
磷酸酯和酸酐具有非常特殊的热力学不稳定性和动力学稳定性，这赋予了它们在生物体内极其宝贵的特性，在生物体内，高效的酶催化剂弥补了它们固有的低反应活性。考虑到它们在蛋白质生物合成中的作用，这些特性在早期阶段引发了一个悖论：在没有酶的情况下，这些物质是如何被选择的？这篇综述旨在证明，考虑混合酸酐或其他比酯和酸酐更具反应活性的物质有助于解决这个悖论。分析了这种方法对化学进化和生命早期阶段的影响。
