Suchalatha S, Thirugnanasambandam P, Maheswaran E, Shyamala Devi C S
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.
Indian J Exp Biol. 2004 Feb;42(2):224-6.
Antioxidant role of Arogh in isoproterenol induced myocardial infarction in rats has been studied. The activity of heart tissue antioxidants like glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-s-transferase were significantly decreased in isoproterenol administered group. The activity of ceruloplasmin and levels of glutathione, vitamins E and C were also found to be substantially decreased in serum with a concomitant rise in lipid peroxide levels after isoproterenol exposure to rats. The synergistic effect of Arogh pretreatment, significantly suppressed the alterations induced by isoproterenol alone in rats.
已对阿罗格在异丙肾上腺素诱导的大鼠心肌梗死中的抗氧化作用进行了研究。在给予异丙肾上腺素的组中，心脏组织抗氧化剂如谷胱甘肽、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽 - S - 转移酶的活性显著降低。在大鼠暴露于异丙肾上腺素后，血清中铜蓝蛋白的活性以及谷胱甘肽、维生素E和C的水平也被发现大幅降低，同时脂质过氧化物水平升高。阿罗格预处理的协同作用显著抑制了异丙肾上腺素单独诱导的大鼠体内的变化。
